Nifedipine versus ritodrine for suppression of preterm labor and analysis of side effects.
نویسندگان
چکیده
OBJECTIVES To compare the tocolytic efficacy of Nifedipine and Ritodrine, their adverse effects and neonatal outcome. DESIGN Prospective randomized trial. METHODS One hundred twenty women with clinical features of preterm labor fulfilling designated inclusion and exclusion criteria were enrolled in the study. They were allocated to either nifedipine group or Ritodrine group by using simple randomization technique. Tocolytic efficacy, maternal side effects and neonatal outcomes were evaluated. Tools of statistical analysis used were Epi Info software and Chi square test. RESULTS Tocolysis was successful i.e., prolongation of pregnancy for 48 h in 54 (90%) women in Nifedipine group as compared to 41 (68.3%) women in Ritodrine group (P value = 0.003 and χ(2) = 8.54). The prolongation of pregnancy up to 37 weeks was observed in 28 women (46.6%) in Nifedipine group compared to 16 women (26.6%) in Ritodrine group (P value = 0.033). 18 women (30%) in Nifedipine group had side effects compared to 48 women (80%) in Ritodrine group (P value < 0.001). Neonatal outcome was similar in both the groups. CONCLUSION Oral Nifedipine is cheaper and effective alternative which has fewer and less serious side effects as compared to I.V. Ritodrine for suppression of the preterm labor.
منابع مشابه
Nifedipine versus ritodrine for suppression of preterm labor; a meta-analysis.
BACKGROUND Since large randomized clinical trials comparing the effectiveness of nifedipine and ritodrine in the suppression of preterm labor are lacking, we performed a meta-analysis on the subject. METHODS We searched the databases Medline and EMBASE using the keywords 'nifedipine', 'ritodrine' and 'randomized' or 'randomised'. The studies were scored for blinding, method of randomization a...
متن کاملA Prospective Randomized Study Comparing Nifedipine versus Ritodrine for the Suppression of Preterm Labour
Nifedipine is a dihydropyridine and a calcium channel blocker during the second phase of the action potential of uterine smooth muscle cells, and ritodrine is a ß-sympathomimetic. Objective of Study: To compare the efficacy and side-effects of oral nifedipine to ritodrine in the inhibition of preterm labour. Methodology: Sixty parturients admitted to the Maternity Hospital with preterm labour w...
متن کاملComparison of effects of nifedipine and ritodrine on maternal and fetal blood flow patterns in preterm labor.
OBJECTIVE The aim of this study was to investigate and compare the effects of nifedipine and ritodrine treatment on fetomaternal blood flow parameters in women with preterm labor. MATERIAL AND METHODS Sixty women with gestational age between 24 and 36 weeks admitted to the obstetrics clinic for preterm labor were enrolled in this study. Patients were randomly assigned to receive either nifedi...
متن کاملمقایسه تاثیر آتوسیبان(آنتاگونیست اکسیتوسین) و نیفدیپین(مهار کننده کانال کلسیم) در کنترل زایمان زودرس و عوارض آنها
The objective of the present study was to compare the effect and complications of (oxytocin antagonist) and nifedipine(Ca channel blocker) for treatment of preterm labor. A randomized clinical trial study was performed on 80 pregnant women with preterm labor between 26-34 weeks of pregnancy in Shahid Akbar Abadi Hospital in Tehran. 40 women(atosiban group) were compared with 40 women(nifedi...
متن کاملپیشگیری از زایمان زودرس: نیفدیپین یا سولفات منیزیم
In this study a comparison was made between the efficacy and side effects of nifedipine and magnesium sulfate in inhibition of preterm labor. 74 cases in preterm labor were randomized to either oral nifedipine (n = 34) or intravenous magnesium sulfate (n = 40). All cases were primigravid with singleton pregnancies and gestational ages of 23-36 weeks. Both groups were similar in terms of age, ge...
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ورودعنوان ژورنال:
- Journal of obstetrics and gynaecology of India
دوره 61 5 شماره
صفحات -
تاریخ انتشار 2011